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Anti-SCIN Rabbit Monoclonal Antibody

     
  • WB - Anti-SCIN Rabbit Monoclonal Antibody ABO16194
    All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
    detail
  • WB - Anti-SCIN Rabbit Monoclonal Antibody ABO16194
    All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
    detail
  • WB - Anti-SCIN Rabbit Monoclonal Antibody ABO16194
    All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
    detail
  • WB - Anti-SCIN Rabbit Monoclonal Antibody ABO16194
    All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
    detail
  • WB - Anti-SCIN Rabbit Monoclonal Antibody ABO16194
    Western blot analysis of SCIN expression in mouse kidney cell lysate.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q9Y6U3
Host Rabbit
Isotype IgG
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Format Liquid
Description Anti-SCIN Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Additional Information
Gene ID 85477
Other Names Scinderin, Adseverin, SCIN {ECO:0000303|PubMed:8547642, ECO:0000312|HGNC:HGNC:21695}
Calculated MW 80 kDa
Application Details WB 1:500-1:2000
IHC 1:50-1:200
Contents Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names Clone: 27S73
Immunogen A synthesized peptide derived from human SCIN
Purification Affinity-chromatography
Storage Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Information
Name SCIN {ECO:0000303|PubMed:8547642, ECO:0000312|HGNC:HGNC:21695}
Function Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:26365202, PubMed:8547642). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
Cellular Location Cytoplasm, cytoskeleton. Cell projection, podosome {ECO:0000250|UniProtKB:Q60604}
Tissue Location Expressed in megakaryocytes.
Research Areas
Citations (0)
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$ 370.00
Cat# ABO16194
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