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> home > Products > Primary Antibodies > Cell Biology > Anti-Phospho-Rad17 (S656) Rabbit Monoclonal Antibody
Anti-Phospho-Rad17 (S656) Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC |
|---|---|
| Primary Accession | O75943 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Phospho-Rad17 (S656) Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human. |
| Gene ID | 5884 |
|---|---|
| Other Names | Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17 {ECO:0000303|PubMed:9878245, ECO:0000312|HGNC:HGNC:9807} |
| Calculated MW | 85 kDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 ICC/IF 1:50-1:200 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 28R30 |
| Immunogen | A synthesized peptide derived from human Phospho-Rad17 (S656) |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | RAD17 {ECO:0000303|PubMed:9878245, ECO:0000312|HGNC:HGNC:9807} |
|---|---|
| Function | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). |
| Cellular Location | Nucleus. Chromosome Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage (PubMed:11799063). Localizes to DNA double-strand breaks (DSBs) (PubMed:24534091). |
| Tissue Location | Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level) Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli Weakly expressed in seminomas (testicular tumors) |
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$ 370.00
Cat# ABO16294
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