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> home > Products > Primary Antibodies > Stem Cells > Anti-Lunatic Fringe Rabbit Monoclonal Antibody
Anti-Lunatic Fringe Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q8NES3 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Lunatic Fringe Rabbit Monoclonal Antibody . Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 3955 |
|---|---|
| Other Names | Beta-1, 3-N-acetylglucosaminyltransferase lunatic fringe, 2.4.1.222, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, LFNG (HGNC:6560) |
| Calculated MW | 41773 Da |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 31L39 |
| Immunogen | A synthesized peptide derived from human Lunatic Fringe |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | LFNG (HGNC:6560) |
|---|---|
| Function | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity). |
| Cellular Location | Golgi apparatus {ECO:0000250|UniProtKB:O09010}. Golgi apparatus membrane; Single-pass type II membrane protein |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO16668
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