DR5 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9QZM4 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42165 Da |
Gene ID | 21933 |
---|---|
Application & Usage | Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 60 kDa DR5 in samples of human and mouse origins |
Other Names | TNFRSF10B, TRICKB, TRANCE-R, ZTNFR9, CD262, TRICK2A, Apo2, TRAIL-R2, TRICK2, KILLER |
Target/Specificity | DR5 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.2 mg/ml) immunoaffinity purified rabbit anti-DR5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | DR5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Tnfrsf10b |
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Synonyms | Dr5, Killer |
Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
Cellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Location | Highly expressed in heart, lung and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DR5 is the DD containing receptor for TRAIL, Apo2, TRAIL-R2, TRICK2, or KILLER. DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. Like DR3 and TNFR1, DR5 mediate apoptosis by FADD dependent pathway. Over-expression of DR5 induces apoptosis and activates NFkB.
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