Jagged 1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q63722 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 134326 Da |
Gene ID | 29146 |
---|---|
Positive Control | 3T3 cell lysate |
Application & Usage | Western Blot analysis (1-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. |
Other Names | CD339 |
Target/Specificity | Jagged 1 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti- Jagged 1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Jagged 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Jag1 |
---|---|
Function | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis. |
Cellular Location | Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250|UniProtKB:P78504} |
Tissue Location | Widely expressed in a variety of tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Jagged belongs to the DeltaSerrateLag2 (DSL) family of ligands that activate LIN12/Notch proteins. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged 1is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Mutation in Jagged1 is associated with an autosomal dominant disorder known as Alagille syndrome and Familial Tetralogy of Fallot a form of complex congenital heart disease.
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