Proinsulin Antibody (Clone HPI-B5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, E |
---|---|
Primary Accession | P01308 |
Reactivity | Human, Pig, Bovine |
Host | Mouse |
Clonality | Monoclonal |
Isotype | Mouse IgG1 |
Clone Names | HPI-B5 |
Calculated MW | 11981 Da |
Gene ID | 3630 |
---|---|
Application & Usage | The antibody can be used for indirect ELISA, WB and IHC. |
Other Names | Proinsulin |
Target/Specificity | ProInsulin |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (1.0 mg/ml) purified mouse monoclonal antibody supplied in PBS with 0.05% (W/V) sodium azide. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Proinsulin Antibody (Clone HPI-B5) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INS |
---|---|
Function | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proinsulin is a prohormone precursor to Insulin, made by the pancreas in response to increased blood s µgar. Proinsulin is 39 amino acids longer than the mature Insulin, of which 4 are completely lost and the remaining 35 forms the C-peptide. The measurement of Proinsulin in serum provides a useful, valuable information for the diagnosis of insulinomas. Proinsulin levels have also been shown to be elevated in non-insulin dependent diabetics (NIDDM), in insulin dependent diabetics (IDDM) and other clinical situations. The antibody recognizes insulin and recombinant proinsulin, but does not react with synthetic C-peptide.
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