Presenilin 2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, IP |
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Primary Accession | P49810 |
Other Accession | NP_036618 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 50140 Da |
Gene ID | 5664 |
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Application & Usage | Western blotting (2-4 µg/ml), immunoprecipitation (20 µg/ml), and Immunohistochemistry (20 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes Presenilin 2 of human, mouse, and rat origins. Reactivity to other species has not been tested. |
Other Names | PSEN1 |
Target/Specificity | Presenilin 2 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Presenilin 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PSEN2 |
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Synonyms | AD4, PS2, PSNL2, STM2 |
Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
Tissue Location | Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer’s disease, probably functioning thro µgh its associated g-secretase activity for amyloid-β protein processing. Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed N-terminal (34 kDa) and C-terminal (~20 kDa) fragments.
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