Fis1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9Y3D6 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 16938 Da |
Gene ID | 51024 |
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Application & Usage | Western blotting (1-4 µg/ml). Per research’s feedback, the antibody can also be used in immunofluorescence. However, the optimal concentrations should be determined individually. The antibody recognizes Fis1 of human, mouse, and rat origins. |
Other Names | hFis1 , TTC11 , H_NH0132A01.6 , CGI-135 |
Target/Specificity | Fis1 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Fis1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FIS1 |
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Synonyms | TTC11 |
Function | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:12783892, PubMed:12861026, PubMed:14996942, PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:12861026, PubMed:16118244, PubMed:23283981, PubMed:23530241, PubMed:24196833). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (PubMed:23530241, PubMed:24196833). Also mediates peroxisomal fission (PubMed:16107562). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (PubMed:24196833). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (PubMed:12783892). |
Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
hFis1 is a novel molecule that was discovered as part of the mammalian fission machinery. Fis 1 has been s µggested to play a role in regulation of the fission processes that might be involved in apoptotic mechanisms.
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