Proteinase Inhibitor 9 (PI9) Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | P50453 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42404 Da |
Gene ID | 5272 |
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Application & Usage | Western blotting (1-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 42 kDa human PI-9. Reactivity to other species has not been tested. |
Other Names | CAP3 , CAP 3 , Cytoplasmic antiase3 PI9 , Protease inhibitor9 ovalbumin type Serpin B9 Serine , Cysteine ase Inhibitor |
Target/Specificity | PI9 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Proteinase Inhibitor 9 (PI9) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SERPINB9 |
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Synonyms | PI9 |
Function | Granzyme B inhibitor. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of capase-1 and, to a smaller extent, caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killing
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