ApoLipoprotein B Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, E, IP |
---|---|
Primary Accession | P04114 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Isotype | Goat IgG |
Calculated MW | 515545 Da |
Gene ID | 338 |
---|---|
Application & Usage | Western blotting (0.5-1 µg/ml), immunoprecipitation (5-10 µg/ml), Immunohistochemistry (5-10 µg/ml) and Elisa (0.5-1 µg/ml). However, the optimal conditions should be determined individually. The antibody reacts with human apoLipoprotein B. It shows negligible cross-reactivity with type A-I, A-II, C-I, C-II, C-III, E, and J apoLipoproteins (<1%). |
Other Names | Apolipoprotein B-100, Apo B-100, Apolipoprotein B-48, Apo B-48, APOB |
Target/Specificity | ApoB |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (1 mg/ml) antigen affinity purified goat anti-apoLipoprotein B polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 0.01% thymersol. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | ApoLipoprotein B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | APOB |
---|---|
Function | Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. |
Cellular Location | Cytoplasm. Secreted. Lipid droplet |
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Provided below are standard protocols that you may find useful for product applications.
Background
Apolipoprotein B consists of a single polypeptide chain with a molecular weight of 549 kDa and is mostly synthesised in the liver. It is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. Normal plasma apolipoprotein B levels are around 800 mg/L.
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