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JLP Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | O60271 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 146205 Da |
| Gene ID | 9043 |
|---|---|
| Application & Usage | Western blotting (1:500 – 1:2500) and Immunoprecipitation. HeLa nuclear extract can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the JLP of human and mouse origins. Reactivity to other species has not been tested. |
| Other Names | JLP, JLP1, JLP-1, JNK-associated leucine zipper protein 1, SPAG9 |
| Target/Specificity | JLP |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | JLP Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPAG9 (HGNC:14524) |
|---|---|
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein- dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q58A65}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q58A65}. Lysosome membrane. Note=Perinuclear distribution in response to stress signals such as UV radiation {ECO:0000250|UniProtKB:Q58A65} |
| Tissue Location | Expressed only in testis on the round spermatids of stage I, II and II. Absent in spermatogonia and spermatocyte [Isoform 3]: Expressed in testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
JLP (JNK-interacting leucine zipper protein) has been identified as a scaffolding protein that functions to position mitogen-activated protein kinases (MAPKs) into specific signaling modules so that successive phosphorylation events of the MAPK pathway can occur. JLP is also known as sperm associated antigen 9 (SPAG9) due to its abundant expression in testicular haploid germ cells.
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