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Anti-Human Myeloperoxidase (MPO) Antibody (Clone 12D06)
Mou Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, E |
|---|---|
| Primary Accession | P05164 |
| Other Accession | EAW94472.1 |
| Reactivity | Human |
| Host | Mou |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1κ |
| Clone Names | 12D06 |
| Calculated MW | 83869 Da |
| Gene ID | 4353 |
|---|---|
| Application & Usage | Myeloperoxidase Sandwich ELISA. This pair is able to detect MPO at < 3 ng/ml. |
| Other Names | 89 kDa myeloperoxidase, 84 kDa myeloperoxidase, Myeloperoxidase light chain, Myeloperoxidase heavy chain |
| Target/Specificity | MPO |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 0.15 M PBS |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-Human Myeloperoxidase (MPO) Antibody (Clone 12D06) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MPO (HGNC:7218) |
|---|---|
| Function | Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971). |
| Cellular Location | Lysosome. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Myeloperoxidase (MPO) is highly expressed in neutrophils and polymorphonuclear luekocytes. MPO is expressed as a dimer in regular neutrophils with a 140 kDA. The glycosylated form of MPO has a molecular weight of 92 kDa and when undergoes a final glycosylation, MPO forms subunits of 60 kDa and 12 kDa. In recent studies, MPO was shown to be involved in the initiation and progression of cardiovascular disease.
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