IP-10 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P48973 |
Reactivity | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 10729 Da |
Gene ID | 245920 |
---|---|
Application & Usage | Western Blot analysis (0.5-1.0 µg/ml), Neutralization (10 µg/ml), and ELISA (2-4 µg/ml). However, the optimal condition should be determined individually. |
Other Names | IP-10, IP10, IP 10, Cxcl10, CXCL10, CXCL-10, CXCL 10, C-X-C motif chemokine 10, Small-inducible cytokine B10; 10 kDa interferon-gamma-induced protein; Gamma-IP10; IP-10 |
Target/Specificity | IP-10 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) purified rabbit anti-rat IP-10 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | IP-10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Cxcl10 |
---|---|
Synonyms | Inp10, Mob1, Scyb10 |
Function | Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity) (PubMed:30257241, PubMed:30448292). |
Cellular Location | Secreted {ECO:0000250|UniProtKB:P02778}. |
Tissue Location | In the central nervous system, CXCL10 is predominantly localized to activated neurons (PubMed:30448292) Expressed in both microglia and astrocytes (PubMed:30257241) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Human IP-10 is an 8.5 kDa protein produced by several cell types during the delayed type hypersensitivity response. IP-10 acts as a chemoattractant towards monocytes, lymphocytes, and certain T cells.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.