Irisin Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q8NAU1 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 23659 Da |
Gene ID | 252995 |
---|---|
Application & Usage | Western Blot - 1: 1000 dilution |
Other Names | Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved) |
Target/Specificity | Irisin |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 1 mg/ml in PBS containing 10% glycerol and 0.02% sodium azide. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Irisin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FNDC5 |
---|---|
Synonyms | FRCP2 |
Function | [Irisin]: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. |
Cellular Location | Cell membrane; Single-pass type I membrane protein Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway. |
Tissue Location | Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen |
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Provided below are standard protocols that you may find useful for product applications.
Background
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
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