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Aldolase C (ALDOC) Antibody (CT)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P09972 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39456 Da |
| Gene ID | 230 |
|---|---|
| Positive Control | Western blot: human brain tissue lysate, IHC: human brain cerebellum. |
| Application & Usage | Western blot: ~1:1000, IHC: ~1:10-1:50. |
| Other Names | ALDOC; ALDC; Fructose-bisphosphate aldolase C; Fructose-bisphosphate aldolase C; Brain-type aldolase |
| Target/Specificity | ALDOC |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µl of antibody in PBS with 0.09% (W/V) sodium azide |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Aldolase C (ALDOC) Antibody (CT) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALDOC |
|---|---|
| Synonyms | ALDC |
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Provided below are standard protocols that you may find useful for product applications.
Background
Fructose 1, 6-bisphosphate aldolase catalyses the reversible condensation of glycerone-P and glyceraldehyde 3-phosphate into fructose 1, 6-bisphosphate. Fructose 1, 6-bisphosphate aldolase exists as three forms, the muscle-specific Aldolase A, the liver-specific aldolase B, and the brain-specific aldolase C. Aldolase A, B, and C arose from a common ancestral gene, from which aldolase B first diverged. Aldolase A is one of the most highly conserved enzymes known, with only about 2% of the residues changing per 100 million years. Aldolase B is regulated by the hormones insulin and glucagon and has been implicated in hereditary fructose intolerance disease. Aldolase C is a polypeptide that is exclusively expressed in Purkinje cells. Aldolase C-positive Purkinje cells are organized in the cerebellum as stripes or bands that run from anterior to posterior across the cerebellum and alternate with bands of Aldolase C-negative Purkinje cells.
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