ANGPTL1 Antibody (NT)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, FC |
---|---|
Primary Accession | O95841 |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 56720 Da |
Gene ID | 9068 |
---|---|
Positive Control | Western blot: HeLa cell lysate, IHC: Human placenta tissue, FACS: HeLa cells. |
Application & Usage | Western blot: ~1:1000, IHC: ~1:50-1:100, FACS: ~1:10–1:50. |
Other Names | ANGPTL1; ANG3; ANGPT3; ARP1; Angiopoietin-related protein 1; Angiopoietin-3; Angiopoietin-like protein 1 |
Target/Specificity | ANGPTL1 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µl of antibody in PBS with 0.09% (W/V) sodium azide |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | ANGPTL1 Antibody (NT) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ANGPTL1 |
---|---|
Synonyms | ANG3, ANGPT3, ARP1 |
Cellular Location | Secreted. |
Tissue Location | Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach |
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Provided below are standard protocols that you may find useful for product applications.
Background
Angptl1 (angiopoietin-like 1), also known as angioarrestin, ARP1, ANGPT3 or previously known as angiopoietin 3 (ANG3), is a member of the angiopoietin-like family. It is highly expressed in adult tissues, particularly adrenal gland, thyroid, placenta and small intestine. Angptl1 exists as a disulfide-linked dimer and shares 45.1% identity with Ang-1 and 59% identity with Angptl2. Angptl1 consists of an N-terminus with a coiled-coil domain, potential glycosylation sites and a C-terminus with a fibrinogen-like domain. It is a secreted protein but does not function as a growth factor in endothelial cells. Angptl1 plays a distinct role in the regulation of angiogenesis; inhibiting proliferation, migration, tube formation and endothelial cell adhesion. To exert this inhibitory activity, Angptl1 is speculated to interact with a receptor on endothelial cells. In a wide variety of tumor tissues, Angptl1 expression is down-regulated suggesting that a major function of this protein involves its antiangiogenic properties.
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