MMP-8 Antibody
Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O88766 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 53277 Da |
Gene ID | 63849 |
---|---|
Other Names | MMP8 , 120355 , P22894 , CLG1 , HNC, PMNL-CL , EC 3.4.24.34 , MMP-8 , Matrix metalloproteinase |
Target/Specificity | MMP-8 |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Background Descriptions | |
Precautions | MMP-8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Mmp8 |
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Function | Can degrade fibrillar type I, II, and III collagens. |
Cellular Location | Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules |
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Provided below are standard protocols that you may find useful for product applications.
Background
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. Unlike other members of the MMP family, MMP-8 is expressed exclusively in inflammatory conditions. MMP-8 is also the predominant collagenase expressed in ulcers and healing wounds.
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