Anti-Beta-galactosidase, Human IgG1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC |
---|---|
Primary Accession | P16278 |
Host | Recombinant |
Clonality | Monoclonal |
Isotype | Human IgG1, lambda |
Calculated MW | 76075 Da |
Gene ID | 2720 |
---|---|
Alias Symbol | GLB1 |
Other Names | beta-gal; Acid beta galactosidase; Beta galactosidase 1; β-galactosidase; β-gal; EBP; ELNR1; Galactosidase beta 1; GLB1; MPS4B |
Appearance | Colorless liquid |
Formulation | 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300 |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Anti-Beta-galactosidase, Human IgG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GLB1 |
---|---|
Synonyms | ELNR1 |
Function | [Isoform 1]: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. |
Cellular Location | [Isoform 1]: Lysosome |
Tissue Location | Detected in placenta (at protein level) (PubMed:8383699). Detected in fibroblasts and testis (PubMed:2511208) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers
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