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WT1

Rabbit Monoclonal antibody(Mab)

     
  • IHC-P - WT1 AD80048-010
    Kidney
    detail
  • IHC - WT1 AD80048-010
    Immunohistochemical analysis of paraffin-embedded human kidney tissue using AD80307 performed on the Abcarta® FAIP-30 Fully automated IHC platform.Tissue was fixed with formaldehyde at room temperature, antigen retrieval was by heat mediation with a EDTA buffer (pH9. 0). Samples were incubated with primary antibody(Ready-to-use) for 15 min at room temperature. AmpSeeTM Detection Systems(Abcepta:AR005) was used as the secondary antibody.
    detail
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Product info
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P19544
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names 401B5E7
Calculated MW 49188 Da
Additional info
Gene ID 7490
Gene Name WT1
Other Names Wilms tumor protein, WT33, WT1
Dilution IHC-P~~Ready-to-use
IHC~~Ready-to-use
Storage This product is stored at 2-321 ℃, please use it within the expiration date.
Precautions WT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WT1
Function Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).
Cellular Location Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190) Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269|PubMed:15520190} Isoform 4: Nucleus, nucleoplasm
Tissue Location Expressed in the kidney and a subset of hematopoietic cells
Research Areas
Citations (0)
citation

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$ 127.00
$ 153.00
$ 182.00
Cat# AD80048-010
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