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LRP
Mouse Monoclonal antibody(Mab)
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- CITATIONS
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- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q07954 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 359E4C2 |
| Calculated MW | 504606 Da |
| Gene ID | 4035 |
|---|---|
| Gene Name | LRP1 |
| Other Names | Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1 (HGNC:6692), A2MR, APR |
| Dilution | IHC-P~~Ready-to-use |
| Storage | This product is stored at 2-198 ℃, please use it within the expiration date. |
| Precautions | LRP Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LRP1 (HGNC:6692) |
|---|---|
| Synonyms | A2MR, APR |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2- macroglobulin receptor (PubMed:26142438). |
| Cellular Location | Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus |
| Tissue Location | Most abundant in liver, brain and lung. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 127.00
$ 153.00
$ 207.00
Cat# AD80325-010
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