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p21
Rabbit Monoclonal antibody(Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P38936 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone Names | 689B1C2 |
| Calculated MW | 18119 Da |
| Gene ID | 1026 |
|---|---|
| Gene Name | CDKN1A |
| Other Names | Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, CDKN1A (HGNC:1784) |
| Dilution | IHC-P~~Ready-to-use |
| Storage | Maintain refrigerated at 2-8°C |
| Precautions | p21/WAF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDKN1A (HGNC:1784) |
|---|---|
| Synonyms | CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WA |
| Function | May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expressed in all adult tissues, with 5-fold lower levels observed in the brain |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AD80498-010
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