SOCS2
Rabbit Monoclonal antibody(Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | O14508 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Clone Names | 445I2A0 |
Calculated MW | 22172 Da |
Gene ID | 8835 |
---|---|
Other Names | Suppressor of cytokine signaling 2, SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2, SOCS2, CIS2, SSI2, STATI2 |
Storage | This product is stored at 2-282 ℃, please use it within the expiration date. |
Name | SOCS2 |
---|---|
Synonyms | CIS2, SSI2, STATI2 |
Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
Tissue Location | High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes. |
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