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Functional LAG-3 Antibody, mAb (blocking) (preservative free)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-F, ICC, E, IP |
|---|---|
| Primary Accession | P18628 |
| Reactivity | Human, Monkey |
| Host | Purified From Concentrated Hybridoma Tissue Culture Supernatant. |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Gene Source | Human |
| Endotoxin | <0.001EU/ µg purified protein or <1EU/mg purified protein (LAL test; Lonza). |
| Application Note | E,Functional Application,Inhibition,ICC,IHC-F,IP(10 µg/ml),WB(5 µg/ml) |
| Clone Names | 11E3 |
| Dilution | WB~~1:1000 IHC-F~~N/A ICC~~N/A E~~N/A IP~~N/A |
| Other Names | Lymphocyte Activation Gene-3; FDC Protein; CD223 |
|---|---|
| Target/Specificity | Recognizes human and monkey LAG-3. |
| Format | Liquid. In PBS containing 0.02% sodium azide. |
| Reconstitution & Storage | Stable for at least 1 year after receipt when stored at -20°C. |
| Precautions | Functional LAG-3 Antibody, mAb (blocking) (preservative free) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
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