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Functional LAG-3 (human) Antibody, mAb (blocking)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-F, ICC, IP |
|---|---|
| Primary Accession | P18629 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Gene Source | Human |
| Endotoxin | <0.001EU/ µg purified protein or <1EU/mg purified protein (LAL test; Lonza). |
| Application Note | Functional Application,Inhibition,ICC,IHC-F (1:150),IP(10 µg/ml),WB(5 µg/ml) |
| Clone Names | 17B4 |
| Calculated MW | 57409 Da |
| Other Names | Lymphocyte Activation Gene-3; FDC Protein; CD223 |
|---|---|
| Target/Specificity | Recognizes human LAG-3. |
| Format | Liquid. In PBS containing 0.02% sodium azide. |
| Reconstitution & Storage | Stable for at least 1 year after receipt when stored at -20°C. |
| Precautions | Functional LAG-3 (human) Antibody, mAb (blocking) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | repR |
|---|---|
| Function | Essential for replication. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
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