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Functional LAG-3 (human) Antibody, mAb (blocking)(preservative free)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-F, ICC, IP |
|---|---|
| Primary Accession | P18630 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Gene Source | Human |
| Endotoxin | <0.001EU/ µg purified protein or <1EU/mg purified protein (LAL test; Lonza). |
| Application Note | Functional Application,Inhibition,ICC,IHC-F (1:150),IP(10 µg/ml),WB(5 µg/ml) |
| Clone Names | 17B4 |
| Calculated MW | 13755 Da |
| Other Names | Lymphocyte Activation Gene-3; FDC Protein; CD223 |
|---|---|
| Target/Specificity | Recognizes human LAG-3. |
| Format | Liquid. In PBS containing 0.02% sodium azide. |
| Reconstitution & Storage | Stable for at least 1 year after receipt when stored at -20°C. |
| Precautions | Functional LAG-3 (human) Antibody, mAb (blocking)(preservative free) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ND3 |
|---|---|
| Synonyms | NAD3 |
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). |
| Cellular Location | Mitochondrion membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
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