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Goat Anti-58KGolgi protein(Internal)/FTCD Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | O95954 |
| Other Accession | NP_996848, 10841 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 58927 Da |
| Gene ID | 10841 |
|---|---|
| Other Names | Formimidoyltransferase-cyclodeaminase, Formiminotransferase-cyclodeaminase, FTCD, LCHC1, Glutamate formimidoyltransferase, 2.1.2.5, Glutamate formiminotransferase, Glutamate formyltransferase, Formimidoyltetrahydrofolate cyclodeaminase, 4.3.1.4, Formiminotetrahydrofolate cyclodeaminase, FTCD |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-58KGolgi protein(Internal)/FTCD Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FTCD |
|---|---|
| Function | Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9YH58}. Golgi apparatus {ECO:0000250|UniProtKB:Q9YH58}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=More abundantly located around the mother centriole |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.
References
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Chapuis J, et al. Mol Psychiatry, 2009 Nov. PMID 19204726.
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). Franke B, et al. Birth Defects Res A Clin Mol Teratol, 2009 Mar. PMID 19161160.
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