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Goat Anti-ARL4D Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P49703 |
| Other Accession | NP_001652, 379, 80981 (mouse) |
| Reactivity | Human |
| Predicted | Mouse, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 22156 Da |
| Gene ID | 379 |
|---|---|
| Other Names | ADP-ribosylation factor-like protein 4D, ADP-ribosylation factor-like protein 4L, ARL4D, ARF4L |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-ARL4D Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARL4D |
|---|---|
| Synonyms | ARF4L |
| Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. |
| Cellular Location | Nucleus, nucleolus. Cell membrane. Nucleus Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS).
References
The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Hofmann I, et al. Curr Biol, 2007 Apr 17. PMID 17398095.
A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome. Fan Y, et al. Nat Genet, 2004 Sep. PMID 15314642.
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