Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Goat Anti-BAALC Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | Q8WXS3 |
| Other Accession | NP_079088, 79870, 118452 (mouse), 140720 (rat) |
| Reactivity | Human, Mouse |
| Predicted | Rat, Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 15551 Da |
| Gene ID | 79870 |
|---|---|
| Other Names | Brain and acute leukemia cytoplasmic protein, BAALC |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-BAALC Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BAALC {ECO:0000303|PubMed:11707601} |
|---|---|
| Function | May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. |
| Cellular Location | Cytoplasm. Synapse, synaptosome {ECO:0000250|UniProtKB:Q920K5}. Membrane raft {ECO:0000250|UniProtKB:Q920K5}. Postsynaptic density {ECO:0000250|UniProtKB:Q920K5}. Note=In neurons, localizes to postsynaptic lipid rafts (By similarity). In myocardial and skeletal muscle cells, localizes to the cytoplasm adjacent to the inner cell membrane, polarized to one end of the myocyte (By similarity) {ECO:0000250|UniProtKB:Q8VHV1, ECO:0000250|UniProtKB:Q920K5} |
| Tissue Location | Predominantly expressed in neuroectoderm-derived tissues. Expressed in the brain and spinal cord, and at low levels, in the adrenal gland. In the bone marrow, confined to the CD34+ progenitor cells. Not found in peripheral blood mononuclear cells, nor lymph nodes. Tends to be expressed at high levels in acute myeloid leukemia and glioblastoma cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines.
References
BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia. Heesch S, et al. Leukemia, 2010 Aug. PMID 20535151.
Prognostic significance of CEBPA mutations and BAALC expression in acute myeloid leukemia Egyptian patients with normal karyotype. El-Sharnouby JA, et al. Egypt J Immunol, 2008. PMID 20306678.
High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia. K脤hnl A, et al. Blood, 2010 May 6. PMID 20065290.
BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML). Santamar铆a C, et al. Ann Hematol, 2010 May. PMID 19943049.
BAALC and ERG expression in acute myeloid leukemia with normal karyotype: impact on prognosis. Eid MA, et al. Int J Lab Hematol, 2010 Apr. PMID 19555438.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
