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Goat Anti-Fibroblast growth factor 21 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, Pep-ELISA |
|---|---|
| Primary Accession | Q9NSA1 |
| Other Accession | NP_061986, 26291 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 22300 Da |
| Gene ID | 26291 |
|---|---|
| Other Names | Fibroblast growth factor 21, FGF-21, FGF21 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-Fibroblast growth factor 21 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FGF21 |
|---|---|
| Function | Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q9JJN1}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
References
FGF21 signalling pathway and metabolic traits - genetic association analysis. Kaess BM, et al. Eur J Hum Genet, 2010 Aug 18. PMID 20717167.
Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels. Cuevas-Ramos D, et al. Eur J Endocrinol, 2010 Sep. PMID 20566587.
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Dushay J, et al. Gastroenterology, 2010 Aug. PMID 20451522.
Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha. Wang Y, et al. J Biol Chem, 2010 May 21. PMID 20332535.
Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa. Fazeli PK, et al. J Clin Endocrinol Metab, 2010 Jan. PMID 19926712.
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