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Goat Anti-MTNR1A Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P48039 |
| Other Accession | NP_005949, 4543 |
| Reactivity | Human |
| Predicted | Mouse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 39375 Da |
| Gene ID | 4543 |
|---|---|
| Other Names | Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor, MTNR1A |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-MTNR1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTNR1A |
|---|---|
| Function | High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
References
Analysis of genetic variations in the human melatonin receptor (MTNR1A, MTNR1B) genes and antipsychotics-induced tardive dyskinesia in schizophrenia. Lai IC, et al. World J Biol Psychiatry, 2010 Aug 23. PMID 20726823.
Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. Chaste P, et al. PLoS One, 2010 Jul 15. PMID 20657642.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Mutation screening of melatonin-related genes in patients with autism spectrum disorders. Jonsson L, et al. BMC Med Genomics, 2010 Apr 8. PMID 20377855.
Melatonin MT1 and MT2 receptor expression in Parkinson's disease. Adi N, et al. Med Sci Monit, 2010 Feb. PMID 20110911.
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