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Goat Anti-Pirin Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O00625 |
| Other Accession | NP_003653, 8544 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 32113 Da |
| Gene ID | 8544 |
|---|---|
| Other Names | Pirin, 1.13.11.24, Probable quercetin 2, 3-dioxygenase PIR, Probable quercetinase, PIR |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-Pirin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PIR |
|---|---|
| Function | Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox- state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). |
| Cellular Location | Nucleus. Cytoplasm Note=Predominantly localized in dot-like subnuclear structures Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. |
| Tissue Location | Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
References
Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches. Licciulli S, et al. BMC Cell Biol, 2010 Jan 20. PMID 20089166.
Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Licciulli S, et al. Leukemia, 2010 Feb. PMID 20010624.
Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese. Tang NL, et al. Bone, 2010 Feb. PMID 19766747.
Structural and biochemical analysis reveal pirins to possess quercetinase activity. Adams M, et al. J Biol Chem, 2005 Aug 5. PMID 15951572.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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