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Goat Anti-XPNPEP1 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NQW7 |
| Other Accession | NP_001161076, 7511, 170750 (mouse), 170751 (rat) |
| Reactivity | Human, Mouse, Rat |
| Predicted | Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 69918 Da |
| Gene ID | 7511 |
|---|---|
| Other Names | Xaa-Pro aminopeptidase 1, 3.4.11.9, Aminoacylproline aminopeptidase, Cytosolic aminopeptidase P, Soluble aminopeptidase P, sAmp, X-Pro aminopeptidase 1, X-prolyl aminopeptidase 1, soluble, XPNPEP1 {ECO:0000312|EMBL:AAH05126.1} |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-XPNPEP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | XPNPEP1 {ECO:0000303|PubMed:10871044, ECO:0000312|HGNC:HGNC:12822} |
|---|---|
| Function | Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg- Pro-Pro (PubMed:11106490, PubMed:35165443, PubMed:18515364). Contributes to the degradation of bradykinin (PubMed:11106490). |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Expressed in all tissues tested, including pancreas, heart, muscle, kidney, liver, lung and brain. Highest levels in pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.
References
Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. Garcia-Barcel贸 MM, et al. Hum Mol Genet, 2010 Jul 15. PMID 20460270.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill. Cilia La Corte AL, et al. J Renin Angiotensin Aldosterone Syst, 2008 Dec. PMID 19126663.
Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit. Li X, et al. J Biol Chem, 2008 Aug 15. PMID 18515364.
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, et al. Am J Hum Genet, 2006 Jan. PMID 16385451.
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