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TRIM37 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | O94972 |
| Other Accession | NP_056109.1, 4591 |
| Predicted | Human, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 107906 Da |
| Gene ID | 4591 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM37, 6.3.2.-, Mulibrey nanism protein, Tripartite motif-containing protein 37, TRIM37 (HGNC:7523) |
| Dilution | E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM37 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM37 {ECO:0000303|PubMed:28724525, ECO:0000312|HGNC:HGNC:7523} |
|---|---|
| Function | E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). |
| Cellular Location | Chromosome. Cytoplasm, perinuclear region. Peroxisome membrane; Peripheral membrane protein. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. |
| Tissue Location | Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein (NP_056109.1; NP_001005207.1).
References
Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism. Avela K, Lipsanen-Nyman M, Idanheimo N, Seemanova E, Rosengren S, Makela TP, Perheentupa J, Chapelle AD, Lehesjoki AE. Nat Genet. 2000 Jul;25(3):298-301. PMID: 10888877
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