DORFIN / RNF19 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q9NV58 |
Other Accession | NP_056250.3, NP_904355.1, 25897 |
Predicted | Human, Pig, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 90696 Da |
Gene ID | 25897 |
---|---|
Other Names | E3 ubiquitin-protein ligase RNF19A, 6.3.2.-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DORFIN / RNF19 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RNF19A |
---|---|
Synonyms | RNF19 |
Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. |
Cellular Location | Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients |
Tissue Location | Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system |
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Provided below are standard protocols that you may find useful for product applications.
Background
Both variants (NP_056250.3; NP_904355.1) encode the same protein.
References
A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G. Biochem Biophys Res Commun. 2001 Mar 2;281(3):706-13. PMID: 11237715
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