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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > P114-RHO-GEF / ARHGEF18 Antibody (C-Term)
P114-RHO-GEF / ARHGEF18 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IP, ICC, E |
|---|---|
| Primary Accession | Q6ZSZ5 |
| Other Accession | NP_056133.2, NP_001124427.1, 23370 |
| Reactivity | Human, Dog, Medaka |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 151642 Da |
| Gene ID | 23370 |
|---|---|
| Other Names | Rho guanine nucleotide exchange factor 18, 114 kDa Rho-specific guanine nucleotide exchange factor, p114-Rho-GEF, p114RhoGEF, Septin-associated RhoGEF, SA-RhoGEF, ARHGEF18, KIAA0521 |
| Dilution | WB~~1:1000 IF~~1:50~200 IP~~N/A ICC~~N/A E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P114-RHO-GEF / ARHGEF18 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGEF18 |
|---|---|
| Synonyms | KIAA0521 |
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Apical cell membrane. Note=In unactivated eosinophils, distributed around the cell periphery in the perimembranous region (PubMed:29601110). In activated eosinophils, relocates to the tip of the nucleopod, a membrane structure formed during activation when the nucleus moves to one end of the cell, and is also concentrated in membrane protrusions at the opposite end of the cell (PubMed:29601110) Localizes to the apical cell membrane in epithelial cells (PubMed:22006950). |
| Tissue Location | Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils (PubMed:29601110). Isoform 2: Expressed in eosinophils (PubMed:29601110). Isoform 3: Expressed in eosinophils (PubMed:29601110). Isoform 4: Not detected in eosinophils (PubMed:29601110). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_056133.2; NP_001124427.1).
References
Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor. Blomquist A, Schworer G, Schablowski H, Psoma A, Lehnen M, Jakobs KH, Rumenapp U. Biochem J. 2000 Dec 1;352 Pt 2:319-25. PMID: 11085924
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$ 423.00
Cat# AF2381a
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