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Neurochondrin Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9UBB6 |
| Other Accession | NP_055099.1, NP_001014841.1, 23154, 26562 (mouse), 89791 (rat) |
| Predicted | Human, Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 78864 Da |
| Gene ID | 23154 |
|---|---|
| Other Names | Neurochondrin, NCDN, KIAA0607 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Neurochondrin Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCDN (HGNC:17597) |
|---|---|
| Synonyms | KIAA0607 |
| Function | Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)- calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). |
| Cellular Location | Cytoplasm, cytosol. Endosome membrane {ECO:0000250|UniProtKB:O35095}; Lipid-anchor. Cell projection, dendrite {ECO:0000250|UniProtKB:O35095}. Postsynapse {ECO:0000250|UniProtKB:O35095}. Note=Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation {ECO:0000250|UniProtKB:O35095} |
| Tissue Location | Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_055099.1; NP_001014841.1). Reported variants represent identical protein (NP_055099.1; NP_001014839.1).
References
Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure. Dateki M, Horii T, Kasuya Y, Mochizuki R, Nagao Y, Ishida J, Sugiyama F, Tanimoto K, Yagami K, Imai H, Fukamizu A. J Biol Chem. 2005 May 27;280(21):20503-8. Epub 2005 Mar 24. PMID: 15790563
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