Carabin / TBC1D10C Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q8IV04 |
Other Accession | NP_940919.1, 374403, 108995 (mouse) |
Predicted | Human, Mouse, Rat, Pig, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 49712 Da |
Gene ID | 374403 |
---|---|
Other Names | Carabin, TBC1 domain family member 10C, TBC1D10C |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Carabin / TBC1D10C Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TBC1D10C |
---|---|
Function | Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. |
Tissue Location | Most abundant in spleen and peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
References
Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. Pan F, Sun L, Kardian DB, Whartenby KA, Pardoll DM, Liu JO. Nature. 2007 Jan 25;445(7126):433-6. Epub 2007 Jan 17. PMID: 17230191
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