UNC45B Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q8IWX7 |
Other Accession | NP_775259.1, NP_001028748.1, 146862, 217012 (mouse), 303373 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 103733 Da |
Gene ID | 146862 |
---|---|
Other Names | Protein unc-45 homolog B, Unc-45B, SMUNC45, UNC45B, CMYA4, UNC45 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | UNC45B Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UNC45B (HGNC:14304) |
---|---|
Synonyms | CMYA4, UNC45 |
Function | Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development. |
Cellular Location | Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CGY6}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage {ECO:0000250|UniProtKB:Q6DGE9} |
Tissue Location | Expressed in eye lens tissues. Expressed in muscle (at protein level) (PubMed:33217308). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both reported isoforms (NP_775259.1and NP_001028748.1).
References
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. Landsverk ML, Li S, Hutagalung AH, Najafov A, Hoppe T, Barral JM, Epstein HF. J Cell Biol. 2007 Apr 23;177(2):205-10. Epub 2007 Apr 16. PMID: 17438072
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.