FKBP8 / FKBP38 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
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Primary Accession | Q14318 |
Other Accession | NP_036313.3, 23770, 14232 (mouse), 290652 (rat) |
Predicted | Human, Mouse, Rat, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 44562 Da |
Gene ID | 23770 |
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Other Names | Peptidyl-prolyl cis-trans isomerase FKBP8, PPIase FKBP8, 5.2.1.8, 38 kDa FK506-binding protein, 38 kDa FKBP, FKBP-38, hFKBP38, FK506-binding protein 8, FKBP-8, FKBPR38, Rotamase, FKBP8, FKBP38 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FKBP8 / FKBP38 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FKBP8 |
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Synonyms | FKBP38 |
Function | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). |
Cellular Location | Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side [Isoform 3]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side |
Tissue Location | Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. |
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Provided below are standard protocols that you may find useful for product applications.
References
Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Wang HQ, Nakaya Y, Du Z, Yamane T, Shirane M, Kudo T, Takeda M, Takebayashi K, Noda Y, Nakayama KI, Nishimura M. Hum Mol Genet. 2005 Jul 1;14(13):1889-902. Epub 2005 May 19. PMID: 15905180
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