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USP21 Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9UK80 |
| Other Accession | NP_036607.3, 27005, 30941 (mouse) |
| Predicted | Human, Mouse, Rat, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 62656 Da |
| Gene ID | 27005 |
|---|---|
| Other Names | Ubiquitin carboxyl-terminal hydrolase 21, 3.4.19.12, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific-processing protease 21, USP21, USP23 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | USP21 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | USP21 {ECO:0000303|PubMed:10799498, ECO:0000312|HGNC:HGNC:12620} |
|---|---|
| Function | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein: NP_001014443.1 NP_036607.3
References
Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. Gong L, Kamitani T, Millas S, Yeh ET. J Biol Chem. 2000 May 12;275(19):14212-6 PMID: 10799498
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