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TCF4 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P15884 |
| Other Accession | NP_001077431.1, NP_003190.1, 6925 |
| Reactivity | Human |
| Predicted | Mouse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 71308 Da |
| Gene ID | 6925 |
|---|---|
| Other Names | Transcription factor 4, TCF-4, Class B basic helix-loop-helix protein 19, bHLHb19, Immunoglobulin transcription factor 2, ITF-2, SL3-3 enhancer factor 2, SEF-2, TCF4, BHLHB19, ITF2, SEF2 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TCF4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TCF4 |
|---|---|
| Synonyms | BHLHB19, ITF2, SEF2 |
| Function | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'- CCANNTGG-3'. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:22777675} |
| Tissue Location | Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise the reported isoforms a and b (NP_001077431.1; NP_003190.1)
References
Tcf3 governs stem cell features and represses cell fate determination in skin. Nguyen H, Rendl M, Fuchs E. Cell. 2006 Oct 6;127(1):171-83. PMID: 17018284
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