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ABCB8 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9NUT2 |
| Other Accession | NP_009119.2, 11194 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 79989 Da |
| Gene ID | 11194 |
|---|---|
| Other Names | ATP-binding cassette sub-family B member 8, mitochondrial, Mitochondrial ATP-binding cassette 1, M-ABC1, ABCB8, MABC1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ABCB8 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCB8 {ECO:0000303|PubMed:25944712, ECO:0000312|HGNC:HGNC:49} |
|---|---|
| Function | ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane (PubMed:31435016). Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (PubMed:31435016). Plays a role in mitochondrial iron transport (PubMed:30623799). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441} |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein. Hogue DL, Liu L, Ling V. J Mol Biol. 1999 Jan 8;285(1):379-89 PMID: 9878413
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