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RPS6KA2 Antibody (C-Term, near)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15349 |
| Other Accession | NP_066958.2, NP_001006933.1, 6196 |
| Reactivity | Rat |
| Predicted | Human, Mouse, Horse |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 83239 Da |
| Gene ID | 6196 |
|---|---|
| Other Names | Ribosomal protein S6 kinase alpha-2, S6K-alpha-2, 2.7.11.1, 90 kDa ribosomal protein S6 kinase 2, p90-RSK 2, p90RSK2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, Ribosomal S6 kinase 3, RSK-3, pp90RSK3, RPS6KA2, MAPKAPK1C, RSK3 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RPS6KA2 Antibody (C-Term, near) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RPS6KA2 |
|---|---|
| Synonyms | MAPKAPK1C, RSK3 |
| Function | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_066958.2; NP_001006933.1)
References
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J Cancer Cell. 2007 Sep;12(3):201-14 PMID: 17785202
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