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NTE Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q8IY17 |
| Other Accession | NP_006693.3, 10908, 50767 (mouse) |
| Predicted | Human, Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 150954 Da |
| Gene ID | 10908 |
|---|---|
| Other Names | Neuropathy target esterase, 3.1.1.5, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NTE Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PNPLA6 (HGNC:16268) |
|---|---|
| Synonyms | NTE |
| Function | Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type III membrane protein |
| Tissue Location | Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Neuropathy target esterase gene mutations cause motor neuron disease. Rainier S, Bui M, Mark E, Thomas D, Tokarz D, Ming L, Delaney C, Richardson
RJ, Albers JW, Matsunami N, Stevens J, Coon H, Leppert M, Fink JK. Am J Hum Genet. 2008 Mar;82(3):780-5. PMID: 18313024
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