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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > GZMA Antibody (internal region)
GZMA Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P12544 |
| Other Accession | NP_006135.1, 3001 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 28999 Da |
| Gene ID | 3001 |
|---|---|
| Other Names | Granzyme A, 3.4.21.78, CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF, GZMA, CTLA3, HFSP |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GZMA Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GZMA {ECO:0000303|PubMed:32299851, ECO:0000312|HGNC:HGNC:4708} |
|---|---|
| Function | Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3257574, PubMed:3262682, PubMed:3263427, PubMed:32299851, PubMed:12819770). It cleaves after Lys or Arg (PubMed:32299851, PubMed:12819770). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death (PubMed:32299851, PubMed:34022140, PubMed:36157507, PubMed:36899106). Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (PubMed:12524539). Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (PubMed:11555662, PubMed:12628186, PubMed:16818237). |
| Cellular Location | [Isoform alpha]: Secreted. Cytoplasmic granule. Note=Delivered into the target cell by perforin. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Martinvalet D, Dykxhoorn DM, Ferrini R, Lieberman J, Cell 2008 May 133 (4): 681-92. PMID: 18485875
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$ 216.00
Cat# AF2947a
Ordering Information
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