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CLEC4C / BDCA2 Antibody (Internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WTT0 |
| Other Accession | NP_569708.1, NP_987099.1, 170482 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 25038 Da |
| Gene ID | 170482 |
|---|---|
| Other Names | C-type lectin domain family 4 member C, Blood dendritic cell antigen 2, BDCA-2, C-type lectin superfamily member 7, Dendritic lectin, CD303, CLEC4C, BDCA2, CLECSF11, CLECSF7, DLEC, HECL |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLEC4C / BDCA2 Antibody (Internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLEC4C |
|---|---|
| Synonyms | BDCA2, CLECSF11, CLECSF7, DLEC, HECL |
| Function | Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose- terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize isoform 1 and 2 (NP_569708.1; NP_987099.1).
References
TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients. Wu P, Wu J, Liu S, Han X, Lu J, Shi Y, Wang J, Lu L, Cao X. Clin Immunol. 2008 Oct;129(1):40-8. Epub 2008 Aug 5. PMID: 18684674
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