GOAT / MBOAT4 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
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Primary Accession | Q96T53 |
Other Accession | NP_001094386.1, 619373, 234155 (mouse), 306515 (rat) |
Predicted | Human, Mouse, Rat |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 49716 Da |
Gene ID | 619373 |
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Other Names | Ghrelin O-acyltransferase, 2.3.1.-, Membrane-bound O-acyltransferase domain-containing protein 4, O-acyltransferase domain-containing protein 4, MBOAT4, GOAT, OACT4 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GOAT / MBOAT4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MBOAT4 (HGNC:32311) |
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Synonyms | GOAT, OACT4 |
Function | Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:24045953, PubMed:18443287, PubMed:25562443, PubMed:28134508). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl- CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:18443287). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0C7A3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P0C7A3} |
Tissue Location | Expressed predominantly in stomach with moderate levels in pancreas and relatively low levels in most other tissues |
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Provided below are standard protocols that you may find useful for product applications.
References
Ghrelin octanoylation mediated by an orphan lipid transferase. Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE, Proceedings of the National Academy of Sciences of the United States of America 2008 Apr 105 (17): 6320-5. PMID: 18443287
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