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DTX2 / Deltext-2 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q86UW9 |
| Other Accession | NP_065943.2, NP_001096066.1, 113878, 304591 (rat) |
| Predicted | Human, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 67246 Da |
| Gene ID | 113878 |
|---|---|
| Other Names | Probable E3 ubiquitin-protein ligase DTX2, 6.3.2.-, Protein deltex-2, Deltex2, hDTX2, RING finger protein 58, DTX2, KIAA1528, RNF58 |
| Dilution | E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DTX2 / Deltext-2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DTX2 |
|---|---|
| Synonyms | KIAA1528, RNF58 |
| Function | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic Partially nuclear. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_065943.2; NP_001096066.1). Reported variants NP_001096065.1, NP_065943.2, NP_001096064.1 represent identical protein.
References
cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. Yi Z, Yi T, Wu Z, DNA sequence : the journal of DNA sequencing and mapping 2006 Jun 17 (3): 175-80. PMID: 17286044
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