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MLX Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q9UH92 |
| Other Accession | NP_937848.1, NP_937847.1, NP_733752.1, 6945, 21428 (mouse), 360631 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 33300 Da |
| Gene ID | 6945 |
|---|---|
| Other Names | Max-like protein X, Class D basic helix-loop-helix protein 13, bHLHd13, Max-like bHLHZip protein, Protein BigMax, Transcription factor-like protein 4, MLX, BHLHD13, TCFL4 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MLX Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MLX |
|---|---|
| Synonyms | BHLHD13, TCFL4 |
| Function | Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. |
| Cellular Location | [Isoform Alpha]: Cytoplasm. Note=Found predominantly in the cytoplasm (PubMed:10918583). [Isoform Gamma]: Nucleus. Note=Found predominantly in the nucleus (PubMed:10918583). |
| Tissue Location | Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all three reported isoforms (NP_937848.1; NP_937847.1; NP_733752.1).
References
Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. Stoltzman CA, Peterson CW, Breen KT, Muoio DM, Billin AN, Ayer DE, Proceedings of the National Academy of Sciences of the United States of America 2008 May 105 (19): 6912-7. PMID: 18458340
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