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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > TTLL4 Antibody (internal region)
TTLL4 Antibody (internal region)
Peptide-affinity purified goat antibody
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Application 
| IHC, E |
|---|---|
| Primary Accession | Q14679 |
| Other Accession | NP_055455.3, 9654, 67534 (mouse), 690512 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 133378 Da |
| Gene ID | 9654 |
|---|---|
| Other Names | Tubulin polyglutamylase TTLL4, 6.-.-.-, Tubulin--tyrosine ligase-like protein 4, TTLL4, KIAA0173 |
| Dilution | IHC~~1:100~500 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TTLL4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TTLL4 (HGNC:28976) |
|---|---|
| Synonyms | KIAA0173 |
| Function | Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side- chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q80UG8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80UG8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80UG8} Note=Located in cilia. In some cells, also found in basal bodies {ECO:0000250|UniProtKB:Q80UG8} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. Trichet V, Ruault M, Roizès G, De Sario A, Gene 2000 Oct 257 (1): 109-17. PMID: 11054573
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$ 423.00
Cat# AF3109a
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